広島大学病院 腎臓内科

研究
学術業績・論文

最新の学位論文や研究活動レポートなど当科の実績をお知らせします。

2020

J Vasc Access. In press, 2020
Different risk factors are associated with vascular access patency after construction and percutaneous transluminal angioplasty in patients starting hemodialysis
Yoshida M, Doi S, Nakashima A, Kyuden Y, Kawai T, Kawaoka K, Takahashi S, Ueno T, Nishizawa Y, Masaki T
Clin Exp Nephrol. In Press, 2020
Initial responsiveness to darbepoetin alfa and its contributing factors in non-dialysis chronic kidney disease patients in Japan
Hayashi T, Kato H, Tanabe K, Nangaku M, Hirakata H, Wada T, Sato H, Yamazaki Y, Masaki T, Kagimura T, Yamamoto H, Hase H, Kamouchi M, Imai E, Mizuno K, Iwasaki M, Akizawa T, Tsubakihara Y, Maruyama S, Narita I
CEN Case Rep. In Press, 2020
A classic variant of Fabry disease in a family with the M296I late-onset variant
Hirashio S, Kagawa R, Tajima G, Masaki T
BMC Nephrol. 21: 376, 2020
A case report of adult-onset COQ8B nephropathy presenting focal segmental glomerulosclerosis with granular swollen podocytes
Maeoka Y, Doi T, Aizawa M, Miyasako K, Hirashio S, Masuda Y, Kishita Y, Okazaki Y, Murayama K, Imasawa T, Hara S, Masaki T
J Med Virol. In Press, 2020
Eighteen-year follow-up cohort study on hepatitis B and C virus infections related long-term prognosis among hemodialysis patients in Hiroshima
Ko K, Nagashima S, Yamamoto C, Takahashi K, Matsuo J, Ohisa M, Akita T, Matyakubov J, Mirzaev U, Katayama K, Masaki T, Tanaka J
Stem Cell Res Ther. 11: 130, 2020
Hypoxia-preconditioned mesenchymal stem cells prevent renal fibrosis and inflammation in ischemia-reperfusion rats
Ishiuchi N, Nakashima A, Doi S, Yoshida K, Maeda S, Kanai R, Yamada Y, Ike T, Doi T, Kato Y, Masaki T
Clin Exp Nephrol. 24: 435-443, 2020
High-normal albuminuria is strongly associated with incident chronic kidney disease in a nondiabetic population with normal range of albuminuria and normal kidney function
Okubo A, Nakashima A, Doi S, Doi T, Ueno T, Maeda K, Tamura R, Yamane K, Masaki T
Hemodial Int. 24: 99-107, 2020
Relationship of serum magnesium level with body composition and survival in hemodialysis patients
Mizuiri S, Nishizawa Y, Yamashita K, Ono K, Usui K, Arita M, Naito T, Doi S, Masaki T, Shigemoto K
CEN Case Rep. 9: 48-54, 2020
Acute tubulointerstitial nephritis and IgM deposits on glomerular capillary walls after immunotherapy with nivolumab for metastatic renal cell carcinoma
Irifuku T, Satoh A, Tani H, Mandai K, Masaki T

2019

Kidney Int. 96: 1162-1175, 2019
Inhibition of the H3K4 methyltransferase MLL1/WDR5 complex attenuates renal senescence in ischemia reperfusion mice by reduction of p16INK4a
Shimoda H, Doi S, Nakashima A, Sasaki K, Doi T, Masaki T
PLoS One. 14: e0218290, 2019
High-normal albuminuria is associated with subclinical atherosclerosis in male population with estimated glomerular filtration rate ≥60 mL/min/1.73 m2: A cross-sectional study
Kimura T, Ueno T, Doi S, Nakashima A, Doi T, Ashitani A, Kawano R, Yamane K, Masaki T
PLoS One. 14: e0218468, 2019
microRNA-200c regulates KLOTHO expression in human kidney cells under oxidative stress
Morii K, Yamasaki S, Doi S, Irifuku T, Sasaki K, Doi T, Nakashima A, Arihiro K, Masaki T
Int Urol Nephrol. 51: 1043-1052, 2019
Hypomagnesemia is not an independent risk factor for mortality in Japanese maintenance hemodialysis patients
Mizuiri S, Nishizawa Y, Yamashita K, Naito T, Ono K, Tanji C, Usui K, Doi S, Masaki T, Shigemoto K
CEN Case Rep. 8: 194-199, 2019
Novel Asp511Thr mutation in McArdle disease with acute kidney injury caused by rhabdomyolysis
Satoh A, Hirashio S, Arima T, Yamada Y, Irifuku T, Ishibashi H, Motoda A, Sueda Y, Masaki T
CEN Case Rep. 8: 266-270, 2019
Atypical reduction of plasma ADAMTS13 activity by a non-IgG-type inhibitor in a patient with hemolytic uremic syndrome caused by Shiga toxin-producing Escherichia coli
Nakayama S, Hirashio S, Yorishima H, Doi T, Yoshida Y, Matsumoto M, Masaki T
Ther Apher Dial. 3: 534-541, 2019
Iliopsoas abscess in hemodialysis patients with end-stage kidney disease
Kawai Y, Banshodani M, Moriishi M, Sato T, Shintaku S, Masaki T, Kawanishi H
J Biol Chem. 294: 101-115, 2019
NFAT5 up-regulates expression of the kidney-specific ubiquitin ligase gene Rnf183 under hypertonic conditions in inner-medullary collecting duct cells
Maeoka Y, Wu Y, Okamoto T, Kanemoto S, Guo XP, Saito A, Asada R, Matsuhisa K, Masaki T, Imaizumi K, Kaneko M
J Artif Organs. 22: 146-153, 2019
Long-term maintenance of hemoglobin levels in hemodialysis patients treated with bi-weekly epoetin beta pegol switched from darbepoetin alfa: a single-center, 12-month observational study in Japan
Kawai T, Kusano Y, Yamada K, Ueda C, Kawai A, Masaki T
Nephrol Dial Transplant. 34: 1592-1596, 2019
Vascular access management after percutaneous transluminal angioplasty using a calcium alginate sheet: a randomized controlled trial
Matsubara M, Banshodani M, Takahashi A, Kawai Y, Saiki T, Yamashita M, Shiraki N, Shintaku S, Moriishi M, Masaki T, Kawanishi H
Int J Mol Sci. 20: 4680, 2019
Xanthine Oxidase Inhibitor Febuxostat Exerts an Anti-Inflammatory Action and Protects against Diabetic Nephropathy Development in KK-Ay Obese Diabetic Mice
Mizuno Y, Yamamotoya T, Nakatsu Y, Ueda K, Matsunaga Y, Inoue MK, Sakoda H, Fujishiro M, Ono H, Kikuchi T, Takahashi M, Morii K, Sasaki K, Masaki T, Asano T, Kushiyama A
Ren Fail. 41: 770-777, 2019
Relationship of matrix Gla protein and vitamin K with vascular calcification in hemodialysis patients
Mizuiri S, Nishizawa Y, Yamashita K, Ono K, Naito T, Tanji C, Usui K, Doi S, Masaki T, Shigemoto K
Diabetol Metab Syndr. 11: 57, 2019
Possible involvement of normalized Pin1 expression level and AMPK activation in the molecular mechanisms underlying renal protective effects of SGLT2 inhibitors in mice
Inoue MK, Matsunaga Y, Nakatsu Y, Yamamotoya T, Ueda K, Kushiyama A, Sakoda H, Fujishiro M, Ono H, Iwashita M, Sano T, Nishimura F, Morii K, Sasaki K, Masaki T, Asano T
Biochem Biophys Res Commun. 514: 436-442, 2019
Renal medullary tonicity regulates RNF183 expression in the collecting ducts via NFAT5
Maeoka Y, Okamoto T, Wu Y, Saito A, Asada R, Matsuhisa K, Terao M, Takada S, Masaki T, Imaizumi K, Kaneko M
Biochem Biophys Res Commun. 514: 217-223, 2019
Calnexin promotes the folding of mutant iduronate 2-sulfatase related to mucopolysaccharidosis type II
Osaki Y, Matsuhisa K, Che W, Kaneko M, Asada R, Masaki T, Imaizumi K, Saito A

2018

Clin Nephrol. 90: 232-236, 2018
Tocilizumab histologically improved AA renal amyloidosis in a patient with multicentric Castleman disease: A case report
Yamada Y, Ueno T, Irifuku T, Nakashima A, Doi S, Ichinohe T, Masaki T
BMC Nephrol. 19: 108, 2018
Favorable effect of bortezomib in dense deposit disease associated with monoclonal gammopathy: a case report
Hirashio S, Satoh A, Arima T, Mandai K, Awaya T, Oshima K, Hara S, Masaki T
Ther Apher Dial. 22: 31-39, 2018
Addition of novel biomarkers for predicting all-cause and cardiovascular mortality in prevalent hemodialysis patients
Yamashita K, Mizuiri S, Nishizawa Y, Shigemoto K, Doi S, Takao Masaki
Am J Physiol Renal Physiol. 315: F300-F312, 2018
Na+-Cl− cotransporter-mediated chloride uptake contributes to hypertension and renal damage in aldosterone-infused rats
Yamauchi T, Doi S, Nakashima A, Doi T, Sohara E, Uchida S, Masaki T
PLoS One. 13: e0196844, 2018
Inhibition of the H3K4 methyltransferase SET7/9 ameliorates peritoneal fibrosis
Tamura R, Doi S, Nakashima A, Sasaki K, Maeda K, Ueno T, Masaki T
J Vasc Access. 19: 477-483, 2018
Comparing the 12-month patency of low- versus high-pressure dilation in failing arteriovenous fistulae: A prospective multicenter trial (YOROI study)
Wakamoto K, Doi S, Nakashima A, Kawai T, Kyuden Y, Naito T, Asai M, Takahashi S, Murakami M, Masaki T
Clin Exp Nephrol. 22: 78-84, 2018
Rationale and design of oBservational clinical Research In chronic kidney disease patients with renal anemia: renal proGnosis in patients with Hyporesponsive anemia To Erythropoiesis-stimulating agents, darbepoetiN alfa (BRIGHTEN Trial)
Kato H, Nangaku M, Hirakata H, Wada T, Hayashi T, Sato H, Yamazaki Y, Masaki T, Kagimura T, Yamamoto H, Hase H, Kamouchi M, Imai E, Mizuno K, Iwasaki M, Akizawa T, Tsubakihara Y, Maruyama S, Narita I
Clin Exp Nephrol. 22: 1167-1173, 2018
pH after the first session of direct hemoperfusion with polymyxin B-immobilized fibers predicts mortality in patients with sepsis and septic shock
Okubo A, Nakashima A, Doi S, Ueno T, Sasaki K, Esaki T, Masaki T
CEN Case Reports. 23: 837-845, 2018
Diffuse large B-cell lymphoma presenting as bilateral renal infiltration leading to acute kidney injury
Okubo T, Hirashio S, Shimizu M, Kuroda Y, Doi S, Masaki T
Clin Exp Nephrol. 22: 835-842, 2018
High-normal albuminuria and incident chronic kidney disease in a male nondiabetic population
Ashitani A, Ueno T, Nakashima A, Doi S, Yamane K, Masaki T
Clin Exp Nephrol. 22: 743-751, 2018
A consensus statement on health-care transition of patients with childhood-onset chronic kidney diseases: providing adequate medical care in adolescence and young adulthood
Kubota W, Honda M, Okada H, Hattori M, Iwano M, Akioka Y, Ashida A, Kawasaki Y, Kiyomoto H, Sako M, Terada Y, Hirano D, Fujieda M, Fujimoto S, Masaki T, Ito S, Uemura O, Gotoh Y, Komatsu Y, Nishi S, Maru M, Narita I, Maruyama S
BMC Nephrol. 19: 143, 2018
A case of immunotactoid glomerulopathy with false-negative IgG staining
Hirashio S, Arima T, Satoh A, Mandai K, Hara S, Masaki T
Hypertension. 72: 746-754, 2018
Dec1 and CLOCK regulate Na+/K+-ATPase β1 subunit expression and blood pressure
Nakashima A, Kawamoto T, Noshiro M, Ueno T, Doi S, Honda K, Maruhashi T, Noma K, Honma S, Masaki T, Higashi Y, Kato Y
PLoS One. 13: e0202409, 2018
Deubiquitinase inhibitor PR-619 reduces Smad4 expression and suppresses renal fibrosis in mice with unilateral ureteral obstruction
Soji K, Doi S, Nakashima A, Sasaki K, Doi T, Masaki T
Sci Rep. 8: 14060, 2018
TGF-β1 promotes expression of fibrosis-related genes through the induction of histone variant H3.3 and histone chaperone HIRA
Shindo T, Doi S, Nakashima A, Sasaki K, Arihiro K, Masaki T
Stem Cells Transl Med. 7: 893-905, 2018
Serum-free medium enhances the immunosuppressive and antifibrotic abilities of mesenchymal stem cells utilized in experimental renal fibrosis
Yoshida K, Nakashima A, Doi S, Ueno T, Okubo T, Kawano KI, Kanawa M, Kato Y, Higashi Y, Masaki T
Cell Death Dis. 9: 808, 2018
Shutdown of ER-associated degradation pathway rescues functions of mutant iduronate 2-sulfatase linked to mucopolysaccharidosis type II
Osaki Y, Saito A, Kanemoto S, Kaneko M, Matsuhisa K, Asada R, Masaki T, Orii K, Fukao T, Tomatsu S, Imaizumi K
Int J Mol Sci. 19: 3967, 2018
The xanthine oxidase inhibitor febuxostat suppresses the progression of IgA nephropathy, possibly via its anti-Inflammatory and anti-fibrotic effects in the gddY mouse model
Inoue MK, Yamamotoya T, Nakatsu Y, Ueda K, Inoue Y, Matsunaga Y, Sakoda H, Fujishiro M, Ono H, Morii K, Sasaki K, Masaki T, Suzuki Y, Asano T, Kushiyama A
Nephrology (Carlton). 23: 837-845, 2018
Coronary artery calcification score and common iliac artery calcification score in non-dialysis CKD patients
Mizuiri S, Nishizawa Y, Yamashita K, Mizuno K, Ishine M, Doi S, Masaki T, Shigemoto K

2017

Kidney Int Rep. 2: 969-972, 2017
A case of fibronectin glomerulopathy caused by missense mutations in the fibronectin 1 gene
Hirashio S, Yamada Y, Mandai K, Hara S, Masaki T
Sci Rep. 7: 1884, 2017
A novel indole compound MA-35 attenuates renal fibrosis by inhibiting both TNF-α and TGF-β1 pathways
Shima H, Sasaki K, Suzuki T,Mukawa C, Obara T, Oba Y, Matsuo A, Kobayashi T, Mishima E, Watanabe S, Akiyama Y, Kikuchi K, Matsuhashi T, Oikawa Y, Nanto F, Akiyama Y, Hsin-Jung Ho, Suzuki C, Saigusa D, Masamune A, Tomioka Y, Masaki T, Ito S, Hayashi K, Abe T
Contrib Nephrol. 189: 178-183, 2017
Klotho as a therapeutic target during the development of renal fibrosis
Doi S, Masaki T.
PLoS One. 12: e0173706, 2017
Inhibition of H3K9 methyltransferase G9a ameliorates methylglyoxal-induced peritoneal fibrosis
Maeda K, Doi S, Nakashima A, Nagai T, Irifuku T, Ueno T, Masaki T
PLoS One. 12: e0178967, 2017
Seasonal variation in hemodialysis initiation: A single-center retrospective analysis
Maeoka Y, Naito T, Irifuku T, Shimizu Y, Ogawa T, Masaki T
Case Rep Nephrol Dial. 7: 102-107, 2017
AA amyloidosis and atypical familial Mediterranean fever with exon 2 and 3 mutations
Yabuuchi J, Hayami N, Hoshino J, Sumida K, Suwabe T, Ueno T, Sekine A, Kawada M, Yamanouchi M, Hiramatsu R, Hasegawa E, Sawa N, Takaichi K, Fujii T, Ohashi K, Migita K, Masaki T, Ubara Y
Clin Exp Nephrol. 21: 771-780, 2017
Valproic acid attenuates renal fibrosis through the induction of autophagy
Kawaoka K, Doi S, Nakashima A, Yamada K, Ueno T, Doi T, Masaki T
Nephrology (Carlton). 22: 947-953, 2017
Oral iron supplementation with sodium ferrous citrate reduces the serum intact and c-terminal fibroblast growth factor 23 levels of maintenance haemodialysis patients
Yamashita K, Mizuiri S, Nizawa Y,Shigemoto K, Doi S, Masaki T
Int J Artif Organs. 41: 135-143, 2017
N-terminal pro_brain natriuretic peptide as a cardiac biomarker in japanese hemodialysis patients
Shimizu M, Doi S, Nakashima A, Naito T, Masaki T
Am J Hypertens. 31: 43-47, 2017
Protective effects of Japanese soybean paste (Miso) on stroke in stroke-prone spontaneously hypertensive rats (SHRSP)
Watanabe H, Sasatani M, Doi T, Masaki T, Satoh K, Yoshizumi M

2016

J Am Soc Nephrol. 27: 203-215, 2016
Inhibition of SET domain-containing lysine methyltransferase 7/9 ameliorates renal fibrosis
Sasaki K, Doi S, Nakashima A, Irifuku T, Yamada K, Kokoroishi K, Ueno T, Doi T, Hida E, Arihiro K, Kohno N, Masaki T
Kidney Int. 89: 147-157, 2016
Inhibition of H3K9 histone methyltransferase G9a attenuates renal fibrosis and retains klotho expression
Irifuku T, Doi S, Sasaki K, Doi T, Nakashima A, Ueno T, Yamada K, Arihiro K, Kohno N, Masaki T
Clin Exp Nephrol. 20: 30-38, 2016
High glucose promotes TGF-β1 production by inducing FOS expression in human peritoneal mesothelial cells
Kokoroishi K, Nakashima A, Doi S, Ueno T, Doi T, Yokoyama Y, Honda K, Kanawa M, Kato Y, Kohno N, Masaki T
Clin Exp Nephrol. 20: 918-925, 2016
Transition of adolescent and young adult patients with childhood-onset chronic kidney disease from pediatric to adult renal services: a nationwide survey in Japan
Hattori M, Iwano M, Sako M, Honda M, Okada H, Akioka Y, Ashida A, Kawasaki Y, Kiyomoto H, Terada Y, Hirano D, Fujieda M, Fujimoto S, Masaki T, Maruyama S, Mastuo S
Hemodial Int. 20: 580-588, 2016
Hypomagnesemia as a predictor of mortality in hemodialysis patients and the role of proton pump inhibitors: A cross-sectional, 1-year, retrospective cohort study
Ago R, Sindo T, Banshodani M, Shintaku S, Moriishi M, Masaki T, Kawanishi H
PLoS One. 11: e0160993, 2016
Linagliptin ameliorates methylglyoxal-induced peritoneal fibrosis in mice
Nagai T, Doi S, Nakashima A, Irifuku T, Sasaki K, Ueno T, Masaki T
J Viral Hepat. 23: 850-856, 2016
Pharmacokinetics, efficacy and safety of daclatasvir plus asunaprevir in dialysis patients with chronic hepatitis C: pilot study
Kawakami Y, Imamura M, Ikeda H, Suzuki M, Arataki K, Moriishi M, Mori N, Kokoroishi K, Katamura Y, Ezaki T, Ueno T, Ide K, Masaki T, Ohdan H, Chayama K

2015

PLoS One. 10: e0129180, 2015
Risk score to predict 1-year mortality after haemodialysis initiation in patients with stage 5 chronic kidney disease under predialysis nephrology care
Doi T, Yamamoto S, Morinaga T, Sada K, Kurita N, Onishi Y
Clin Exp Nephrol. 19: 830-837, 2015
Expression of age-related factors during the development of renal damage in patients with IgA nephropathy
Yamada K, Doi S, Nakashima A, Kawaoka K, Ueno T, Doi T, Yokoyama Y, Arihiro K, Kohno N, Masaki T
Ther Apher Dial. 19: 245-249, 2015
Hemodialysis immediately after cardiac catheterization is a risk factor for intradialytic hypotension
Irifuku T, Naito T, Ogawa T, Shimizu Y, Maeoka Y, Masaki T
Intern Med. 54: 887-894, 2015
The serum lipids levels may be underestimated in patients on hemodialysis
Ueno T, Doi S, Nakashima A, Yokoyama Y, Doi T, Kawai T, Kusano Y, Ueda C, Masaki T
Clin Exp Nephrol. 19: 631-638, 2015
Efficacy of add-on therapy of aliskiren to an angiotensin II receptor blocker on renal outcomes in advanced-stage chronic kidney disease: a prospective, randomized, open-label study
Soji K, Doi S, Nakashima A, Sasaki K, Kawai T, Aoki A, Kyuden Y, Fujiwara K, Yokoyama Y, Masaki T
J Vasc Access. 16: S58-61, 2015
Vascular access intervention by a nephrologist in Hiroshima
Doi S, Masaki T

2014

Clin Exp Nephrol. 18: 499-506, 2014
Low serum testosterone is associated with atherosclerosis in postmenopausal women undergoing hemodialysis
Shiraki N, Nakashima A, Doi S, Carrero Juan Jesus, Sugiya N, Ueno T, Stenvinkel Peter, Kohno N, Masaki T
PLoS One. 9: e93513, 2014
Mizoribine ameliorates renal injury and hypertension along with the attenuation of renal caspase-1 expression in aldosterone-salt-treated rats
Doi T, Doi S, Nakashima A, Ueno T, Yokoyama Y, Kohno N, Masak T
Clin Nephrol. 82: 268-272, 2014
Successful treatment with plasma exchange for ANCA-negative pauci-immune crescentic glomerulonephritis with D-negative hemolytic uremic syndrome
Irifuku T, Naito T, Ogawa T,Masaki T
Clin Nephrol. 18: 189-193, 2014
Characteristic kidney pathology, gene abnormality and treatments in LCAT deficiency
Hirashio S, Ueno T, Naito T, Masaki T
Clin J Am Soc Nephrol. 9: 2117-2122, 2014
Telomeric g-tail length and hospitalization for cardiovascular events in hemodialysis patients
Hirashio S, Nakashima A, Doi S, Anno K, Aoki E, Shimamoto A, Yorioka N, Kohno N, Masaki T, Tahara H

2013

Kidney Int. 84: 297-307, 2013
Mesenchymal stem cells ameliorate experimental peritoneal fibrosis by suppressing inflammation and inhibiting TGF-β1 signaling
Ueno T, Nakashima A, Doi S, Kawamoto T, Honda K, Yokoyama Y, Doi T, Higashi Y, Yorioka N, Kato Y, Kohno N, Masaki T

2012

Clin Exp Nephrol. 16: 921-929, 2012
Morning blood pressure is useful for detection of left ventricular hypertrophy in hemodialysis patients
Ago R, Nakashima A, Naito T, Doi S, Ochiai M, Hamaguchi N, Yokoyama Y, Tanaka J, Yorioka N, Masaki T, Kohno N
CEN Case Rep. 1: 24-28, 2012
A case of renal hypouricemia and a G774A gene mutation causing acute renal injury that was improved by hemodialysis
Hirashio S, Yamada K, Naito T, Masaki T

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