Department of Nephrology, Hiroshima University Hospital

Details of research

Recently, we reported that inhibition of H3K4 histone methyltransferase (SET7/9) and H3K9 histone methyltransferase (G9a) ameliorate renal fibrosis and clarified the association between epigenetics and the progression of renal fibrosis. We are also conducting research into the inhibitory effects of (1) mesenchymal stem cells and (2) a specific drug on the progression of renal and peritoneal fibrosis.

We are conducting basic research to answer clinical questions with a consequent focus on drug discovery. Moreover, our research emphasizes the establishment of preventive measures against chronic kidney disease (CKD) progression through cohort study.

Basic research

1. Mechanisms for the suppression of renal and peritoneal fibrosis.
2. Pathophysiology and treatment of salt-sensitive hypertension.
3. Involvement of senescence-associated factors such as Klotho in the progression of renal and peritoneal fibrosis.

Clinical Research

1. Risk factors associated with the incidence of CKD.
2. Effect of phosphate binders on urinary biomarkers in CKD patients.
3. Morbidity and mortality from cardiovascular disease in hemodialysis patients.
4. Patency of fistulas in vascular access intervention.